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KMID : 0357919770110020113
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Korean Journal of Pathology
1977 Volume.11 No. 2 p.113 ~ p.118
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A Comparative Study of tee-White Coagulation Time and Activated Coagulation Time (ACT) in Heparinized Rabbits
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맹국영(孟國永)/KooK young Maeng
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Abstract
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A comparative study of Lee-White coagulation time and activated coagulation time
(ACT)using celite in heparinized rabbits was carried out.
Initially, baseline values of both tests were measured before heparin administration.
Then, heparin of varying dose (200unit/kg b.w. in one and 1000unit/kg b.w. in the
other) were injected. Exactly after one hour, coagulation time and ACT were measured
simultaneously using three syringe tectnic. Since then, coagulation time and ACT were
measured at an hour interval every hour after heparin injection through 9 hour
thereafter.
Lee-White method was observed to be unstable and fluctuating, and to be poor
measure for heparin monitoring. Values of ACT plotted on semilogarithmic graph,
however, revealed linear drop reflecting semilogarithmic decay of anticoagulant effect of
heparin injected.
These observations were consistent with those observations of Hattersley, Bull and
others, who said that ACT Precisely reflected semilogarithmic decay of heparin injected
and preferred ACT to conventional Lee-White coagulation time in many clinical use
including control of heparin therapy in various conditions.
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